β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1
نویسندگان
چکیده
منابع مشابه
Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.
Overwhelming of protein folding in the endoplasmic reticulum (ER)--referred to as "ER stress"--activates a set of intracellular signaling pathways termed the unfolded protein response (UPR). Beneficial outputs of the UPR promote adaptation in cells experiencing manageably low levels of ER stress. However, if ER stress reaches critically high levels, the UPR uses destructive outputs to trigger p...
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ankylosing spondylitis (as) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. according to recent studies, erap1 is the second most common candidate gene for as susceptibility after hla-b27. the aim of this study was to determine the association of erap1 gene polymorphisms with as in iranian population. the study group comprised 387 iranian as patients and 316 h...
متن کاملTLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.
Macrophages play an important role in host defense under several immunological, inflammatory, and/or infectious conditions. In our previous work, we demonstrated that endoplasmic reticulum aminopeptidase 1 (ERAP1) was secreted from macrophages in response to LPS and IFN-γ, and it enhanced their phagocytic activity. In this study, we analyzed the mechanism of LPS/IFN-γ-induced ERAP1 secretion. L...
متن کاملEndoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response
Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating global innate immune responses has not been described to date. Here we demonstrate that, relative to wild type mice, mice lacking ERAP1 exhibit exa...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2020
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db19-0984